Now that she is single again, Kathy plans on jumping back into the dating pool and making a big splash by dating someone who will get her all the publicity that she needs. First in the mix is Nick Carter, whom she ends up going out with, but whose publicist tries to maintain the encounter out of the press.

Kathy is ready to set out on Rosie O'Donnell's lesbian cruise, but soon realizes that she must adjust her comedic material to captivate the lesbian audience. To do so, she enlists assistance from "Work Out" star Jackie Warner. However, and to her dismay, Kathy's comedy is not her only impediment, as she receives horrible news that may shake the entire course of her life from this point forward.

Following her tragic family loss, Kathy begins to ponder her legacy and wishes to resolve all her relationship issues. In the meantime, she is also offered a gig on a home-shopping network, hosts a performance in her hometown Chicago, and reconnects with an old high-school love.

Kathy gears up to host a gay adult-video awards gala. She also prepares to perform her comedy act in front of prisoners at a state penitentiary in Arizona.

Kathy and her posse journey to jolly old England for some D-list (mis)adventure and to promote the UK run of “Kathy Griffin: My Life on the D-List.”

In the third-season finale, Kathy scores an award from Irish America magazine. The recognition inspires Kathy to connect with her Irish roots, so she journeys with her posse to Dublin, where she offers a sweet gesture in memory of her father.