The drama tells the story of Tang Jiayu, a female cardiac surgeon who has been practicing medicine abroad for many years. She was invited by Vice President Liu Feng to return to China to serve as the director of the Heart Center at Beijing Anhe Jisheng Hospital. From just being acquainted with Ouyang Zhenyu, the director of the medical department, to gradually developing into a confidant with Ye Yiming, an anesthesiologist. At the same time, she led five members of the ICU team: Jiang Bailie, Long Xiangdong, Qin Dazhong, Zhou Da, and Liao Xiaobo to jointly treat 28 rare heart disease cases, and in the continuous growth boosted the successful development of the domestic "full magnetic levitation artificial heart," rewriting the history of cardiac surgery in China, and at the same time realize self-redemption and harvest happiness.