Kim tries to get the confidence to take a boy to an upcoming dance at her school, while Kim's archenemy, Drakken begins his next destructive plan.

When Kim catches a cold from her brothers before a mission, she soon discovers that it’s hard to save the world when you’re not feeling well. Dr. Drakken and Shego exploit the moment to steal a laser from the research lab Kim is guarding. However, when Kim’s sickness begins to spread, a series of events occurred that not even she could expect.

To help his son's ongoing quest to become a pop sensation, Senor Senior, Senior kidnaps the Oh Boyz band to blackmail the record company. The plan backfires when Ron winds up captured along with the group. The record executive, finding the Oh Boyz' disappearance to be a profit windfall, is in no hurry to help so Kim must find Ron and the others on her own.

Kim investigates a string of celebrity robberies, but comes up empty-handed. Meanwhile, the tweebs enter Middleton High School as freshmen. Ashley Tisdale guest stars.