Professor Shepherd must call together a group of awesome dogs to stop General Parvo from gaining an important weapon. Shepard names his dogs the "Road Rovers," and they set off on their first mission: to duel the General Parvo, his Lieutenant Groomer, and the first two Cano-Mutants.

The Rovers have to find a stolen device that could destroy the world. They are pitted against a new enemy, Captain Zachary Storm, a militant who was discharged from the military and is now out for revenge.

The Road Rovers travel to England to fight a group of werewolves wreaking havoc. They return to MissionControl seemingly safe, but when ""werewolfy"" things start happening there, it is obvious that one of their teammates is infected. But which Road Rover is it? And can they stop their infected comrade before he/she destroys mankind? (Not to mention devouring all their kibble!)

When a sceptor is stolen, the Road Rovers attempt to create a peace between two warring countries with the aid of a pack of wolves by embarking on a mission to recover the sceptor without getting themselves caught.

General Parvo has a new crazed scheme! He wants to awaken a dinosaur family and use them to wreak havoc! He enlists the help of a band of Shiba Inu Cano-Mutant Ninjas. The Rovers must stop them from stealing artifacts that could lead to disaster, so they travel to Japan!

A small dog from San Francisco witnesses the kidnapping of his master! The Rovers find and rescue him, and he is trans-dogmified to go to court to testify with the aid of the Road Rovers, who have no idea what they are in for. Will they be caught themselves?

Parvo is now running an operation of kidnapped dogs! Colleen and Shag sneak themselves into the facility where they find not just a few dogs, but hundreds! Parvo's plan is to transform them into his servants at his leisure! How will Colleen and Shag escape? And will they rescue every single one of the dognapped pups?

The Groomer defies Parvo and retreats to Egypt with three of her felo-mutants! The Rovers must stop the new breed of enemies, the Felo-sapiens, (human cats). A startling revelation about an enemy is revealed when Groomer tries an ancient Egyptian ritual to grant herself eternal life.

General Parvo's new plan is just letting his new breed of fighters destroy the world! The Road Rovers find themselves facing three mutant insects! They receive no help from Muzzle, who has fallen head-over-paws in love with Parvo's female rottweiler, Greta. Will they deal? Will Greta leave Parvo to join the RRs?

A deep declining decrease in the world currency/gold market sends the Rovers out on a mission to recover the gold in South America. They meet a young boy who happens to be blind. His dog has been stolen by mutant pirhana fish. Will they save him?

The Rovers' owners - the world leaders - are brainwashed into warring with one another because of an extra-terrestrial force! It is up to the Road Rovers to save them, and the whole world from nuclear war!

Ever wondered how the Rovers manage their lives? The Road Rovers go out on a normal day of missions. It is discovered that Hunter carries with him a photo of a beautiful female dog, whom the Rovers assume to be his girlfriend. Who is she?