After he is summoned unknowingly by Ben Pitcher to treat one of his cows,a human patient of Doc's dies. Durning a fight with Pitcher, Doc is knifed.

After his friend Ben Williams is shot down by Lou Shippen, Matt travels to Elkader to bring him him. The only problem, he doesn't know what he looks like and the town is protecting Shippen.

Matt closes up shops to a group of drunken cowboys, which causes trouble.

After gunman, Sam Kercher is killed by Matt, his 16-year old brother arrives to fight Matt.

At Fort Dodge, home of the third cavalry, Mrs. Mary Cullen tells the colonel that the twelve year old white boy they recovered from the Cheyenne is her son Dennis. The tribe had taken him when he was two years old.

Matt is used by an old friend (Andrew Duggan) in a con game (Simon Oakland appears).

Doc comes upon a homesteader (Philip Bourneuf) with a busted leg and a gun to protect himself from his wife (Cloris Leachman).

Matt leaves Dodge City unprotected when he sets out to find a killer (Mike Connors) (Bert Rumsey credited as 'Bartender', but referred to by Chester as 'Sam Noonan').

An outlaw (Claude Akins) threatens to kill Doc if he does not help his wounded buddy (Frank de Kova and Amzie Strickland appear).

Matt and Chester act as decoys to ambush outlaws (including Mickey Simpson) that are masking their crimes as those of renegade Indians (Fintan Meyler and Herbert Rudley appear).

Matt discovers that he was the intended victim of a murder he is investigating (Stanley Adams, Jack Kruschen, Paul Newlan, Harry Townes, and H. M. Wynant appear).

Matt helps a woman (Constance Ford) whose suitors (including Denver Pyle) are about to duel for her affections.

A landowner (Paul Fix) tries to terrorize homesteaders (Bartlett Robinson and Peg Hillias) off their land (Gordon Gebert, John Smith, and Stuart Whitman appear).

An old buffalo hunter (Edgar Stehli) swears revenge on the skinner (Grant Withers) that left him to die (Richard Deacon appears as banker Botkin, Bert Rumsey credited as 'Bartender').

Matt traps a cattleman (Tyler McVey) who shot two homesteaders (including Roy Engel) (Malcolm Atterbury and Vivi Janiss appear).

An Indian woman (Angie Dickinson) faces prejudice for her father's raid on Dodge City (Peter Whitney and Paul Wexler appear).

A bank robber (Robert H. Harris) murders his wife and frames Tobeel (Frank de Kova) for the crime (Paul Lambert appears).

A young gunfighter, Tom Clegg, forces farmer Abe Curry into a duel and kills him. Matt can't arrest Clegg since Abe drew first. However, Abe's brother Morgan plots revenge. Morgan, who is unarmed, follows Clegg constantly. Clegg soon grows tired of it and attempts to take care of his ""problem.""

Townspeople protect an outlaw (Carl Betz) they believe has reformed (Tige Andrews, Joe De Santis, John Dierkes, Marianne Stewart, and Ward Wood appear).

The shooting of several members of an outlaw gang, though in self defense, triggers an emotional crisis in Matt, haunted by memories of all the men he has killed (Lawrence Dobkin, Russell Johnson, and Gloria Marshall appear).

An Eastern girl makes the long trip to Dodge, only to find that her fiancé has lost his money and won't marry her.

Rena Decker, a new dance hall girl, purposely gets her admirers into fighting over her. Despite Kitty's negative opinion of her, Matt befreinds Rena and gets her a job at the Long Branch. Soon afterward, 4 men are dead and Rena is the cause.

Ex-gunslinger Joel Adams' past is about to catch up with him.

A Washington official is determined to tame Dodge City.

Kitty gets annoyed by a pair of old farmers who are each trying to have a fling with her.

Chester is drinking at the Long Branch and gets into an argument with a gambler over a girl. When the marshal breaks it up, he tells Chester to bring the man to jail. On the way there the man is killed and everyone thinks Chester did it. Matt has to prove Chester is innocent.

Dodge City meets a Photographer who shows the residents how a camera works. Jacoby wants to take pictures of how the Wild West looks. When Matt learns someone died, he thinks the photographer may have hired someone to kill Grubby for a picture of the west.

A cowboy vows revenge for the shooting of his friend, who was mistaken for a criminal (Don Keefer and Catherine McLeod, real-life husband and wife, appear as a husband and wife).

Philip Locke is looking for Laura Simmons, a saloon girl, but she doesn't want him to know where she works. Laura tells Matt that she and Philip were previously engaged, and she asks him not to say anything about her job. Philip warns Matt that he will be killed if he doesn't tell the truth.

Matt fakes his death to lure a gunman (Vic Perrin) out in the open (Robert Karnes appears, Bert Rumsey credited as 'Sam').

A former gunfighter has turned away from violence, but his fiancee's brother is determined to goad him into a gunfight.

After Charlie Brewer is found dead, Jack Salter who was a friend of Charlie Brewer comes to Matt's office saying Vint killed Brewer. Matt then tries to find out if Jack is right.

Joe Delk causes trouble at The Long Branch after shooting two men who were unarmed.

Matt goes after an outlaw (Earle Hodgins) who shot Chester (Paul Wexler appears).

Kitty's father, Wayne Russell, arrives in Dodge to meet his daughter after abandoning her and her mother as a baby. He insists that saloon life is not fit for a proper lady and wants to take her back to New Orleans so he can pamper her and invest her savings in his freight business.

A former Army Officer wants Matt Dillon's job. Matt then takes Mr. Egan on his rounds. Matt lets Egan try his brand of justice that almost costs Egan his life.

A braggart tries to provoke a gunfight with a harmless drunk.

Jack Kelly plays a hot-tempered husband who thinks Matt is after his wife.