Le Dr George Coleman est au sommet de sa gloire, lorsqu'il apprend que son ex-petite amie, Dorothy Crane, vient d'hériter de l'hôpital dans lequel il travaille. Il n'est pas vraiment ravi de la savoir devenue sa patronne. Alors que George préfère passer du temps avec les animaux plutôt que leurs maîtres, Dorothy, elle, recherche la compagnie humaine. Les tensions entre eux deux mettent mal à l'aise le reste du personnel de l'hôpital, dont Rizzo, un petit capucin et meilleur ami de George...

Doug tries to convince George to operate on his dog, and Angela sells off Rizzo's artwork.

Yamamoto confronts his fear of puppets, and Dorothy tries to cure Angela of her hankering for bad boys.

Yams becomes an NYC hero and Dorothy hires George's nemesis.

George must save the life of his mother's cat or face terrible consequences: spending time with her.

George begins to feel threatened with Jill's strong new presence at the hospital. Annoyed by this increasing competition, George attempts to sabotage one of Jill's operations. Meanwhile, Dorothy takes on judging Crane Animal Hospital's Halloween pet costume contest and struggles with the temptation to take a bribe.

George begins treating a cockatoo that keeps mysteriously ingesting chocolate. While George tries to manage the eccentric owner, Sabrina French, Doug sets his sights on the socialite granddaughter, Tinsley French. Dorothy begins a movie night but when only Yamamoto shows up the two make the most of it. Meanwhile, Angela and Dr. Rizzo have to call the cable guy when their favorite legal program “Law of the Jungle,” is interrupted. Smitten with the cable guy’s take-charge manner, Angela schemes to get him back ASAP.

Dr. George Coleman and Dorothy Crane disagree on how best to deal with an overweight dog, “Ralphie,” and the over-indulging owner who is over-feeding him. George prefers threats and humiliation while Dorothy prefers a gentler approach. Meanwhile, Dorothy establishes a weekly “snack & chat,” which conflicts with the guys’ poker night.