La saison 1 de Dr. Emily Owens a été diffusée à partir du 16 octobre 2012.

Emily Owens is now a first-year intern at Denver Memorial Hospital, where she'll have the chance to work with world-famous cardiologist Dr. Gina Beckett—and where, not-so-coincidentally, her med-school crush Will Rider is also an intern. Emily soon finds out her high school nemesis, the gorgeous, popular Cassandra Kopelson, is also just starting out at Denver Memorial, and it seems like they're rivals all over again—not only as surgical interns, but for Will's attention. The cliques at Denver Memorial are all too familiar: the jocks have become orthopedic surgeons; the mean girls are in plastics; and the rebels are in the ER. Emily will have to balance the personal and emotional turmoil of social politics with the high-stakes world of life-and-death medical decisions.