La acción se sitúa en Nápoles, Italia. Koichi tiene que viajar allí para recabar información sobre un joven a petición de Jotaro. ¿Quién será ese misterioso joven?

Bucciarati quiere enfrentarse a Giorno para cumplir las órdenes de su jefe, pero pronto descubrirá que es un usuario de Stand. Y que tiene un Stand de lo más problemático.

Giorno tiene un objetivo muy claro, y para ello tendrá que entrar en la banda que controla la ciudad. Pero antes tendrá que conocer al líder para que este le dé su aprobación.

La prueba de ingreso que le puso Polpo a Giorno se ha complicado por un pequeño accidente. Dicho accidente ha provocado que un Stand letal lo ataque.

La muerte de Polpo en misteriosas circunstancias tiene a la gente de la banda un tanto intranquila. Además, circula un rumor de que ocultaba un enorme tesoro que nadie sabe dónde puede estar.

La situación en el yate es crítica. Ya solo quedan a salvo Bucciarati y Abbacchio, y si quieren salir con vida y rescatar al resto deberán resolver el misterio del Stand del enemigo.

La situación en el barco ya está controlada, pero antes de que lo apresaran, su enemigo se puso en contacto con un compañero y ya sabe adónde van y con qué fin.

Mista emprende la persecución para evitar que Sala, su enemigo, se le escape y se apodere del tesoro escondido de Polpo.

A Bucciarati y el resto les llega una misión encomendada directamente por el misterioso jefe de Passione, que es ni más ni menos que proteger a su hija.

Narancia se enfrenta a Formaggio, uno de los integrantes del misterioso equipo de asesinato que va atenta contra la vida de Trish, la hija del jefe de Passione.

Durante su enfrentamiento contra Formaggio, la historia nos mostrará cómo fue la juventud de Narancia hasta llegar a conocer a Bucciarati y su entrada en Passione

Abbacchio, Fugo y Giorno tienen que viajar a Pompeya para cumplir la segunda misión que les encomienda su jefe, pero al poco de llegar descubren que no están solos.

The person hiding in the mirror was Illuso from the Hitman Team. Fugo ends up being dragged into the mirror by Illuso's Stand, Man in the Mirror. Fugo then summons his own Stand, Purple Haze. Despite Giorno wanting to find Fugo, Abbacchio decides to go look for the key, since that was their mission. However, once Abbacchio finds the key, he also gets dragged into the mirror world...

"Take Trish to Venice." With their next order from the boss, Bucciarati and his crew head to Naples Station. "Use the key at the water fountain with the turtle on the 6th platform." They find the water fountain, but can't find the place to use the key. Meanwhile, Proscuitto and Pesci from the Hitman Team follow Bucciarati and the others to Naples Station. Bucciarati figures out the mystery behind the key and gets on the express train to Florence, and Proscuitto and Pesci follow.

The Grateful Dead slowly begins to age everybody on the train. With his teammates affected, Mista goes alone to confront the enemy, only to encounter Pesci and his Beach Boy.

After defeating Proscuitto and Pesci, Bucciarati and the others head to Venice in a car. Melone from the Hitman Team finds some of Bucciarati's blood at the scene where the train had stopped and then activates Babyface. The powerful remote-control Stand created by assaulting a woman on the train then goes after Bucciarati.

Using Babyface's Stand's ability to turn human parts into other things, Giorno uses his Golden Wind to make parts for the human body. He rebuilds his own body and fights back. Meanwhile, another member of the Hitman Team who's also after Trish, Ghiaccio, was trying to regroup with Melone and was driving to Giorno's location.

Ghiaccio's Stand, White Album is able to envelop him like a bodysuit and able to freeze everything around him to extremely low temperatures. Giorno and Mista somewhat make it to Venice, despite being partially frozen by Ghiaccio. But in order to try to get away from Ghiaccio, Giorno drives their car into the canal and they get stuck. Mista tries to sacrifice himself, but Giorno tells him that what's important right now isn't for him to sacrifice himself but for him to have resolve.

Mista and Giorno were able to defeat Ghiaccio. They then confirm the mission on the disc and head to the location they're supposed to take Trish. Bucciarati goes up the tower with Trish, but while they're in the elevator, Trish suddenly disappears. Bucciarati then realizes what the boss's true motives are.

Bucciarati finds out that the boss's true motive is to eliminate Trish because of her relationship with him, causing him to betray the boss and save Trish. Meanwhile, Giorno feels something bizarre is going on as they waited for Bucciarati's return. The boss's Stand, King Crimson rises.

Because of their own wills and their sense of justice, Bucciarati and the others end up betraying the organization. Trish also wants to find out who her father truly is, so she tells the others that her mother met her father in Sardinia. They all decide to have a meal in Venice before they leave and Narancia is suddenly attacked by a Stand. The boss's own personal elite guard was now on the move.

The Stand that attacked Narancia was named Crush and belonged to Squallo, a member of the boss's elite guard. On top of that, Narancia suddenly can only say the exact opposite of what he's thinking, thanks to the ability of Talking Mouth, the Stand of Squallo's partner, Tiziano. Using Narancia, Squallo and Tiziano throw the team into chaos. The two elite guard members put Narancia in danger, but he boldly faces them so they can get out of Venice safely.

After defeating Squallo and Tiziano, Bucciarati and the others head off to Sardinia to find out about the boss's past. They head to Marco Polo International Airport in order to get a jet, but a strange man was following them. Mista manages to kill the strange Stand user before they're able to call upon their Stand. Even though they're a bit put off at how simple that was, they get onto the jet and fly off. But once they're on the jet, Giorno hears a weird noise...

Trapped in the cabin of a flying plane with Notorious B.I.G, Trish has noticed that Giorno's brooch is turning into a brand new hand that will allow him to regain his powers. However, the movement of the transformation is attracting the enemy Stand. As the plane approaches the Tyrrhenian Sea, Trish must now try to protect both the hand of Giorno and herself from Notorious B.I.G.

On the island of Sardinia, a boy named Doppio is searching for Trish and the others on orders from Passione's boss. But Doppio has a dark secret, one that becomes apparent when he encounters Risotto of La Squadra.

Doppio, the alter ego of Passione's boss, continues to fight against Risotto and his iron controlling Metallica. Doppio struggles against the powerful assassin, but is armed with King Crimson's Epitaph, which allows him to see the future.

In the aftermath of the battle between Risotto and Doppio, Abbacchio uses Moody Blues to try and uncover the boss's identity. But the boss is adamant about keeping his identity a secret and executes his next gambit against the group.

After his death, Abbacchio was able to leave the others a copy of the boss’s face and fingerprints with Moody Blues' replay. The others try to find out who the boss is with the fingerprint and suddenly get contacted by someone. The mysterious man tells them that the boss’s name is Diavolo and tells them that the secret behind defeating him lies in the arrow. Bucciarati and the others head to Rome to meet him.

The gang are under attack by the last two members of the Elite Squad. Cioccolata uses his Green Day to spread a toxic mold over the island while Secco uses Oasis to swim through rock for stealth attacks, leaving the gang in a pinch.

While Bruno stays on the ground to fight against Secco's Oasis, Giorno and Mista head upwards towards Cioccolata to stop the power of his Green Day. But Cioccolata has another dangerous trick up his sleeve, pushing the two into a corner.

Bruno and Secco are both racing towards the man at the Colloseum whilst trying to kill each other.

Bruno unknowingly leads Doppio to the Colosseum while the rest of the gang is searching for their leader.

Everyone wakes up from a deep sleep to discover their souls have been swapped.

The gang desperately tries to reach the Stand arrow whilst looking for Diavolo.

Everyone continues to desperately chase after the Requiem in order to obtain the Stand arrow. Diavolo's soul is then forced to show itself, but he will not quit until he obtains the arrow for himself.

The Stand arrow's rightful owner is finally revealed.

Giorno achieves his dream and destiny of becoming a Gang-star.

In the past, Bruno and his team investigated the mysterious death of a girl and how it ties into the power known as Rolling Stones. And in the present, the final fate of Giorno and the gang is revealed as Golden Wind comes to a close.