Den synske TV-kjendisen Patrick Jane hjelper politiet med å oppklare forbrytelser. Han bruker sine velutviklede observasjonsevner til å løse vanskelige mordsaker og avsløre de skyldige. (S2, Ep1)

Lisbon og CBI etterforsker drapet på en fremstående senators praktikant, mens Jane prøver å få tak i ny informasjon om Red John.

Jane, Cho, Rigsby and Van Pelt decide to conduct their own investigation when Lisbon is accused of murdering a child molester she arrested who was recently paroled.

Jane og CBI etterforsker mordet på den mektige advokaten Gordon Hodge, som var ansvarlig for at en morder ble frikjent.

Jane and the CBI team are called in to investigate the death of a prominent architect found murdered in a crumbling old mansion, and there appears to be a number of suspects.

Even after Bosco arrests Jane and puts him in prison for spying on him, Jane is able to help the CBI team from his cell to solve the murder of a young man.

Bosco og Lisbon må samarbeide i en kidnappingssak, og deres ulike fremgangsmåter skaper dårlig stemning blant resten av teamet.

CBI-teamet opplever en voldelig forbrytelse på sitt eget kontor og må etterforske saken. Samtidig blir det tydelig at det er noe på gang mellom Rigsby og Van Pelt.

Patrick Jane and the team are called to investigate the robbery and murder of a wealthy jeweler while attending a black tie fundraiser for the CBI.

Jane and company investigate the murder of a man and his wife, on her way to his fifteen year high school reunion where, clearly, the attendees haven't changed all that much.

Patrick Jane and the team investigate the murder of a mayor's aide, and Rigsby and Van Pelt make a big announcement.

Patrick Jane and the CBI team investigate when the body of a high-end luxury car sales woman is found in the trunk of a Bentley in the dealership's showroom.

When a member of Cho's former gang, the Avon Park Playboys, is found murdered, Patrick Jane insists on helping Cho with his off-the-books investigation.

Jane and the team investigate the murder of an arrogant chef during a cooking competition in Napa Valley.

When Dr. Alicia Seberg, a government research scientist, is exposed to a deadly toxin while at work and has only hours to live, she calls Patrick Jane and the CBI to find her murderer.

Patrick and the CBI team investigate the murder of a tutor, and find a mysterious little red box near the body, starting a chain of events that turns the murder into the search for a priceless ring stolen from the British Museum. Meanwhile, Lisbon is worried when a new boss, Madeleine Hightower, takes command of the CBI, as well as mysteriously learning about Rigsby and Van Pelt's relationship.

When a "Jane Doe" with amnesia and covered in blood steps in front of Cho and Van Pelt's car, Patrick Jane must use all of his skills to discover who she is, her last location and why she lost her memory

When Patrick Jane's sneaky conduct causes the case of a confessed hitman to be tossed out of court, his annoyed CBI team must start the investigation over from scratch.

When a media mogul is murdered, Patrick Jane and the CBI team investigate cult leader Bret Stiles, who may have had an axe to grind following the publication of a critical story about his group.

Patrick Jane and the CBI team investigate the death of a mathematical genius by a gun-wielding clown.

Romantic sparks begin to fly when Patrick Jane and supposed psychic Kristina Frye cross paths again during the CBI investigation into the murder of a charismatic head of a non-profit organization that fights human trafficking.

Patrick Jane and Kristina's first date is interrupted by a report of Red John striking again, which is discovered to be a copycat. But when Kristina reaches out to the real Red John, both she and Jane find themselves in grave danger.