Ash och hans vänner återvänder till Pallet Town för ett entusiastiskt välkomnande, men skickas genast på en ny resa! Professor Oak letar efter en Poké Ball med mystiskt utseende och han ber Ash, Brock och Misty att hitta den.

Våra hjältar förbereder den långa resan till Valencia-ön, där de ska hämta en mystisk Poké Ball åt professor Oak. Ash vinner en gratis Blimp-tur och då verkar deras färdsätt vara löst; men vem är det som flyger luftskeppet?

Efter en kraschlandning på Valencia-ön, visas våra hjältar vägen till professor Ivys lab där den mystiska Poké Ballen är. Brock blir förtjust då han får veta att professor Ivy och hennes kolleger också är Pokémon-uppfödare!

På grund av Jigglypuffs sövande sång kommer luftskeppet, som är på hemväg med Ash och Misty, ur kurs och kraschar på en ö, där de träffar en ny vän som heter Tracey, medan de försöker rädda en Lapras.

Ash, Misty och Tracey ger sig av för att utforska Orange-öarna, och Ash är fast besluten att kvalificera sig till Orange-ligan! Han inser snart att det är skillnad på att utmana Orange-teamet och en vanlig gymstrid.

När Ash, Misty och Tracey kommer till Mandarin-ön, blir Pikachu och Togepi fientliga och går med en grupp arga Pokémon! När de bråkiga Pokémon är borta, berättar konstapel Jenny att dussintals Pokémon har anmälts försvunna.

Ash hittar ett meddelande i en flaska som leder våra hjältar in i nya äventyr på Sunburst-ön, och sökandet efter en mycket speciell Onix!

Våra hjältar befinner sig på Pinkan-ön, där det bor ett stort antal märkligt färgade Pokémon. Ash och Tracey är mycket fascinerade av dessa rosa Pokémon.. och det är även Team Rocket-trion!

Efter att ha följt med på en forskningsexpedition för att undersöka Kabuto-fossil, står Ash och vännerna plötsligt öga mot öga med en hel rad naturkatastrofer

Misty meets another female trainer who also is an expert on water Pokémon. The new trainer notices some signs that Misty's Psyduck may be ready to evolve. As the two prepare for a Pokémon battle, a Golduck springs from the water and battles for Misty. With her powerful new Pokémon, can Misty defeat both her newfound friend and Team Rocket?

Ännu en Vatten-typ specialist utmanar Misty på en strid, och ger henne också tips; hon tror att Mistys Psyduck kan vara redo för att utvecklas!

Våra hjältar möter en mycket upptagen Syster Joy som måste resa intensivt mellan öarna för att ta hand om alla Pokémon i området! Kan de skydda henne från Team Rocket?

Under Ashs andra utmaning av Orange Ligan måste han bestiga ett berg, bygga en bob, och vinna ett slädlopp! Har hans Pokémon vad som krävs för att hjälpa honom att klara alla dessa hinder?

Våra hjältars utforskande tar dem till de sju Grapefruktöarna, där de får veta att öarnas berömda frukt har försvunnit! Ash, Misty och Tracey försöker fånga de som är ansvariga för försvinnandet.

Några dykare har funnit en urgammal Orange Ligan-mästerskapstrofé, och våra hjältar går direkt till konstmuséet för att titta på den! Tyvärr hinner Team Rocket före dem..!

När Team Rocket kraschar på en ö, hamnar Meowth i fokus då lokalbefolkningen felaktigt tror att han är ”Överflödets Store Meowth”, ett mäktigt väsen som omtalas i en profetia. Vad kommer att hända när de får veta sanningen?

Arriving on Murcott Island, Ash and his friends discover a wounded Scyther. After capturing it, Tracey must take it to a Pokémon Center. While there, he discovers the Scyther got dethroned from being in charge of his group.

Deciding to take a break on a nearby island, Ash, his friends, and all their Pokémon just use the time to relax and get better acquainted. However, Team Rocket has other plans for the Pokémon and intend to steal them.

The group descend on Mandarin Island where Ash's arrogance emerges due to the fact that he's won every single battle he's had since arriving on the island but upon meeting Prima, a member of the Elite Four and challenging her to a battle, Ash starts to realize that he may have made a grave mistake.

Still on Mandarin Island, Ash and his friends go through Victorian Town where they find two Nidoran who are in love with each other but any possible hint of a relationship is being derailed by the trainers who happen to be childhood rivals.

Ash and his friends discover a man who has troops of Magnemite and has to take them to a town on the island in order to give it power. However, he gets injured, so it is up to Ash to herd up the Magnemite and get to the town.

Heading to the other end of Mandarin Island, Ash and his friends discover there's a monster in the sewer that is causing lots of problems in the town. When the Mayor wants to blow it up, Joy protests and asks Ash and company to help.

Ash arrives on Trovita Island prepared to battle for his third Orange League Gym Badge. However, much to Ash's dismay, the Gym Leader, Rudy has more than just battling on his mind, Rudy develops a crush on Misty, and Ash gets jealous once again. Rudy moves in to court Misty after she helps rescue his younger sister, Mahri. While Ash battles for the Spike Shell Badge, Misty considers the tempting offer to stay on the island with Rudy and Mahri forever.

After getting his 3rd Orange League Badge, Ash and his friends arrive on an island, where Pikachu is soon captured by Team Rocket and is chained to Meowth. But soon after Pikachu and Meowth are taken away by a giant Pidgeot, the trapped rivals eventually learn how to get along.

After hearing about Ash from the Trovita Island gym leader, another trainer seeks him out for a battle. When Pikachu is knocked out during the battle, Ash turns to his Charizard, but he struggles to make the unruly Pokémon listen to him.

On the next island, Ash and his friends see a team of firefighters consisting of Squirtles, Wartortles, and Blastoises. Eager to test its skills, Ash's Squirtle get to train with them. But when an actual fire turns up, training has to become reality.

While in a battle, Ash accidentally breaks Snorlax's Pokéball. With the Pokémon Center on the other side of the island, Ash and his friends have to get Snorlax there. And to make matters worse, Team Rocket arrive and are hoarding the island's food ransom until they get Pikachu.

On Kumquat Island, Ash discovers Luana, the final Orange Island Gym Leader, who mistakes him for her son. After defending the island from Team Rocket, they head to the Gym to have a Double Battle where Pikachu and Charizard battle against Marowak and Alakazam but Pikachu's and Charizard's unwillingness to work together might end up costing Ash his chance of qualifying for the Orange League.

On Rind Island, Tracey meets Dr. Quackenpoker, a noted Pokémon Watcher who is doing a study on the Magikarp that climb up waterfalls and how they evolve into Gyarados. However, Team Rocket appears to steal the Magikarp and get them to evolve.

After winning his way to the final competition for the Orange League Winner's Trophy, victory seems a long shot for Ash as the Gym Leader deploys a powerful Gengar that topples one of Ash's Pokémon after another.

As if a gym battle with a Dragonite isn't challenge enough for one day, Team Rocket secretly surveys the weakened state of Ash's battling Pokémon and plots to turn the situation to their advantage.

It's piracy on the open seas and Ash and friends must rescue a local school of Lapras from would-be poachers, but how can they be of help when the Lapras, conditioned to fear humans, shun the young Trainers?

Having to travel by boat, Ash and his friends arrive on Hamlin Island, their final stop before returning to Kanto to discover that the town is being attacked by hundreds of Electrode. A man named Poncho is trying to stop them with his Diglett.

They’re back in Pallet Town. When they get home, they discover Brock is back and he won’t explain why he left Valencia Island. However, as usual, Team Rocket try to steal all of the Pokémon in Oak’s lab by vacuuming all the Pokéballs, including the GS Ball that Oak was working on. Can they get it back?

An errand of Professor Oak's sets Ash on the road once again, but first he must face his old hometown rival, Gary, in a Pokémon battle.