The Juni Taisen takes place every twelve years. The participating warriors must kill each other until only one remains. Inonoshishi, Warrior of the Boar and the daughter of the last Taisen's winner, ends up fighting her first enemy in an unexpected way.

Warrior of the Dog, Dotsuku, is known for his powerful bite, "Mad Dog's Vise." However, he has a secret skill: the ability to create and secrete a variety of poisons from his body. This gives him an advantage when all of the participants are poisoned!

Warrior of the Chicken, Niwatori, isn't as powerful as the others, but her ability to see with a birds-eye-view has helped her survive many battles. She can also betray without feeling any remorse, until she first meets the Monkey Warrior, Sharyu.

Warrior of the Monkey, Sharyu, is a powerful fighter able to manipulate the three states of matter, but uses her power to bring peace around the world. She seeks peace at the Juni Taisen as well, until her lone ally asks if people are really worth saving.

Warrior of the Ram, Hitsujii, is a legendary warrior and winner of the 9th Juni Taisen. In this new Taisen, Hitsujii ranks the other warriors by their abilities and plots a scheme using the poison Juseki crystal.

Warrior of the Horse, Uuma, has trained his body to its limits to acquire the ultimate defensive technique, "Stirrup." But his confidence in that ability faltered during his meeting with the Warrior of the Ox.

Warrior of the Snake, the younger Tatsumi Brother, is a dangerous individual who would have become a pyromaniac if he hadn't become a warrior. On their way to the Juni Taisen, he remembers the day his brother saved his life.

Warrior of the Dragon, the elder Tatsumi Brother, is an arrogant but cool-headed warrior who acts as commander when working with his brother. Using his "Heaven's Holding" ability to fly, he watches over Snake and waits for his chance to join the battle.

Warrior of the Rabbit, Usagi, is a Necromantist who makes other warriors into his "friends." Warrior of the Ox, Ushii, and Warrior of the Tiger, Tora, end up facing off against two of these "friends," the Tatsumi Brothers.

The Warrior of the Ox, Ushii, is seen by other fighters as extremely powerful. The genius combatant uses his systematic killing style to slaughter any enemy he comes across.

Nezumi, Warrior of the Rat, is an ordinary high school student in his normal life. He used his ability, Hundred Paths of Nezumi-san, to become the Taisen's lone survivor, and in the process learned the wishes of the battle's other participants.