Vic Reeves Big Night Out is a British cult comedy stage show and later TV series which ran on Channel 4 for two series in 1990 and 1991, as well as a New Year special. It marked the beginnings of the collaboration between Vic Reeves and Bob Mortimer and started their Vic and Bob comedy double act.

The show was later acknowledged as a seminal force in British comedy throughout the 1990s and which continues to the present day.

Arguably the most surreal of the pair's work, Vic Reeves Big Night Out was effectively a parody of the variety shows which dominated the early years of television, but which were, by the early 1990s, falling from grace. Vic, introduced by Patrick Allen as "Britain's Top Light Entertainer and Singer", would sit behind a cluttered desk talking nonsense and introducing the various segments and surreal guests on the show. Vic Reeves Big Night Out is notable as the only time in their career where Vic solely took the role of host, while Bob was consigned to the back stage, appearing every few minutes as either himself or as a strange character. The two received equal billing in the series credits.

On 3 October 2007, the first episode was re-broadcast on More4 as part of Channel 4 at 25, a season of classic Channel 4 programmes shown to celebrate the channel's 25th birthday.