After centuries in which the Catholic Church has controlled thought and ideas, one city at the heart of fifteenth century Europe is poised on the threshold of an intellectual and artistic revolution. Cosimo de’ Medici and his father have established the world’s largest banking business, whose ‘clients’ include popes and princes. Outwitting his political rivals and establishing his family at the heart of Republican Florence, Cosimo uses his phenomenal wealth to scour the continent for relics of antiquity, breathing new life into the study of the ancient past. As Cosimo’s power grows, his friend Brunelleschi builds a great dome over the cathedral of Florence. It will become the greatest achievement in western architecture since ancient times. Donatello and Lippi create original works for the Medici family, and a religious festival is held in Florence, sparking a new explosion of classical learning and inventive thinking. Florence flourishes as a new Rome. When Cosimo dies, the Florentine republic declares him “Father of the Nation”.

Withstanding attacks from bitter enemies, including the Pope, Cosimo’s young grandson Lorenzo becomes a driving force of the Renaissance. When his beloved brother is assassinated, his supporters take instant revenge on those that stand against the Medici family. With his power reinforced, Lorenzo delivers in full the creative revolution conceived by his grandfather. Some of the greatest artistic genius the world has ever known flourishes under Lorenzo: Michelangelo, Botticelli, Leonardo da Vinci, and more – and Florence is hailed as the cultural capital of the world. But a vicious backlash emerges. A young monk named Savonarola rails publicly against the decadence and sinfulness of the city. When Lorenzo dies in 1492, his family is driven from the city and Savonarola leads Florence in a fury of fundamentalist purification. Jewellery, wigs, fancy clothes and many great works of art are destroyed in the now infamous ‘bonfire of the vanities’.

By 1512 Giovanni de’ Medici — although exiled from Florence — has become the most senior cardinal at the Vatican. With the power of the Papacy behind him, he returns to the city, seizing it with brutal force. When the Pope dies in 1513, Medici money ensures the quick accession of Giovanni to the Papacy. Taking the name Pope Leo X, he embarks on a frenzy of overspending, depleting papal funds. To raise money, he sells Indulgences — papal forgiveness for sin — on an unprecedented scale. When a German monk named Martin Luther protests, it sparks a revolutionary fire that quickly spreads across Europe. After Leo’s death, his cousin Giulio becomes Pope Clement VII. The second Medici Pope, he continues the family tradition of patronage, commissioning Michelangelo to build magnificent tombs for the Medici family. But his political machinations backfire, and Charles V declares war on Rome. In 1527, Rome is sacked. Though seemingly defeated, the Medici family will soon expand their power. In 1533, Catherine de’ Medici marries the son of the King of France. As Queen, she will reign supreme in France.