Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.

Max navigates his diagnosis while Dr. Sharpe encourages him to make a plan. Meanwhile, Dr. Bloom encourages Reynolds to take a chance and Dr. Kapoor and Iggy work together to help a child.

Reynolds begins to build his department as Dr. Sharpe battles skepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.

Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.

Max faces the pressure of his first fundraising gala at the hospital; Frome struggles to break difficult news to his daughter; Bloom and Reynolds deal with the fallout of their argument; Kapoor and Sharpe work to help a sick father and son.

With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.

A patient's treatment plan takes an unexpected turn when Max gets overly invested. Meanwhile, Reynolds celebrates his birthday with some help from the hospital and Kapoor grapples with a case that hits close to home.

Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.

As Max fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. As the team feels Max's absence and the doctors find out that they may have to treat one of their own, Sharpe must finally come clean about Max's condition.

Reynolds confronts a difficult episode from his past. Max distracts himself from chemotherapy by taking on the case of a frequent-flyer patient. Frome helps a young man suffering from severe delusions. Sharpe worries about Bloom's attempt to detox.

Tensions are high in the hospital as Bloom is overruled on a diagnosis. Meanwhile, Iggy notices that something may be amiss with one of the hospital's most respected surgeons.

Max continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom must face her personal demons head-on.

Sharpe struggles when a case hits too close to home. Frome uncovers a patient's surprising past. Reynolds makes progress in his personal life after some difficult news.

Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds has difficulty handling a personal matter regarding a patient's family and Iggy struggles with a realization regarding his daughter.

When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.

As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on. Reynolds must get creative as he continues to work to save Hugh with very few resources.

Reynolds struggles to help a young cystic fibrosis patient with curious symptoms. Kapoor finally comes face-to-face with Ella after their awkward encounter. Sharpe takes a major step in her personal life.

When a NYPD officer is hit by a car in the line of duty, the hospital is turn upside down trying to save her. Meanwhile, Kapoor and Iggy work with a patient struggling with a previous surgery.

Max is forced to reckon with his diagnosis in a new way as things become more difficult for him. Meanwhile, Reynolds is forced to address what could have gone wrong in a recent surgery.

Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance. Iggy struggles with an accusation brought against him. Sharpe navigates her role as deputy medical director.

Sharpe works on a creative way to help Max and Kapoor gets surprising news. Meanwhile, Reynolds takes a big step in his relationship with Evie as one of the doctors makes a life altering decision.