Stała obsada sezonu 8

1. 

   Christopher Daniel Barnes

   Peter Parker / Spider-Man (voice)

2. 

   Sara Ballantine

   Mary Jane Watson (voice)

3. 

   Jennifer Hale

   Felicia Hardy (voice)

4. 

   Linda Gary

   Aunt May Parker (voice)

5. 

   Gary Imhoff

   Harry Osborn (voice)

6. 

   Ed Asner

   J. Jonah Jameson (voice)

7. 

   Rodney Saulsberry

   Joe "Robbie" Robertson (voice)

8. 

   Roscoe Lee Browne

   Kingpin (voice)

Goście specjalni 7

1. 

   Stan Lee

   The Man (voice)

2. 

   Brian Keith

   Uncle Ben (voice)

3. 

   Patrick Labyorteaux

   Flash Thompson (voice)

4. 

   Joan Lee

   Madame Web (voice)

5. 

   Earl Boen

   Beyonder (voice)

6. 

   Mary Kay Bergman

   Gwen Stacy (voice)

7. 

   Majel Barrett

   Anna Watson (voice)

Ekipa 2