With COVID-19 devastating the country, two gunmen take out their desperation and rage on the elite class they perceive to be oppressing them; Jess' father returns and may not be over his old ways.

When a hacker triggers a car crash that kills a family of three, the team races to hunt him down as his ransomware demands escalate and his final target becomes apparent.

After witnessing her husband's murder, a woman is kidnapped from her home along with a mysterious stash of money hidden in her floor. When Jess realizes there may be a connection to one of his past cases, the need to find the kidnapper becomes personal.

The team searches for a young woman who is heading down a deadly path of vengeance, using ties to an online radical conspiracy organization to further her cause. Also, Barnes must make a life-changing decision, finding it hard to not let the dark side of her job affect her.

After a rogue militia group opens fire on several teenagers crossing the Canadian border into the U.S., the team races to find the ringleader and his final target. Also, Jess' relationship with his father, Byron reaches a breaking point.

After a robbery gone wrong ends with a murder and kidnapping, the team races to rescue a mother and daughter whose abductors are not what they seem. Also, Crosby enters a new living arrangement.

After a suspect escapes trial and goes on a murder spree, the team partners with his bail bondsperson, Jackie, in order to track him down. Also, Jess continues to struggle with moving forward in his love life.

The team chases an unlikely serial killer whose end game takes a shocking turn. Also, Hana returns from medical leave, and Jess and Sarah's relationship continues to evolve.

After Crosby's old army buddy is attacked in an apparent drug deal gone wrong, the team's quest for answers uncovers a dangerous web of conspiracy. Also, Jess questions his relationship with Sarah after an unexpected encounter.

After a double murder takes place in a small town, the team goes after the vigilante who relies on internet sleuths to exact revenge on suspects in the name of justice. Also, Jess and Sarah's relationship continues to grow, but not everyone approves.

When a young man accidentally shoots a cop in self-defense and goes on the run, the team members find themselves in a moral dilemma on the best way to carry out justice. Also, Barnes and her wife struggle with their plans to have another child.

The team tracks two brothers set on getting revenge against members of the company that caused their town's environmental destruction. Also, Sarah meets the rest of the LaCroix family, including Jess' sister, Louise.

The team heads to D.C. to protect Ortiz's former informant after a hitman tries to kill her. Also, Sarah helps Jess' family prepares for Byron and Marie's last-minute wedding on Jess' farm.

Jess and the Most Wanted team head to Tennessee to track down an undercover DEA agent who appears to have turned dirty amid a major drug ring operation. Also, Sarah wonders if it was a mistake to move in with Jess and Tali so soon.