When a family of four from New York is found dead in a Georgia motel room, the Fugitive Task Force investigates a connection between the victims and the sale of illegal firearms. Also, Barnes struggles with Remy's leadership style upon her return from maternity leave, and Remy and his sister plan for their mother's care.

Rookie agent Ray Cannon joins the Fugitive Task Force as they hunt down a mysterious killer targeting IRS offices.

After a heist in the Diamond District leaves three dead, the team's search for the fugitives reveals a dangerous connection to Kristin’s undercover past in Miami.

The murder of a geology professor leads the team to uncover an ancient legend regarding a secret treasure dating to the civil war, and they encounter a deadly fugitive determined to kill to find the gold. Meanwhile, an old friend from Remy's past shakes up his relationship with April.

After Hana is kidnapped while trying to help a young girl in peril at a rest stop that's on the way to her sister's house in Connecticut, Remy and the team pull out all the stops to find her.

After a tech entrepreneur is abducted from a rave in Brooklyn and found bludgeoned to death at his estate in Connecticut, Remy and the team must dive into the world of psychedelics to find his killer.

The team's Thanksgiving plans are put on hold when they are brought in to investigate whether a shooting at a Buddhist temple was a hate crime or something more personal. Also, Remy and April make a tough decision.

When three prosecutors are assassinated outside a bar in their small Arkansas town, the team is called in to determine if this was a personal vendetta; Ray feels compelled to help a woman and her young son combat an injustice.

When a celebrity child psychiatrist is kidnapped by the relative of a former client, the team races to track down the perpetrator and learns what really happened to the psychiatrist's client; Kristin confronts her deep-rooted trauma.

The team is thrown for a loop when they discover the abductor of a disgraced state police detective is connected to someone from a recent case.

As the team chases after the suspects behind an explosion at an Ohio energy plant, they are led towards a major crypto company with enemies looking to take it down; Remy and his sister close a chapter in their lives.

When two Vermont teens are kidnapped on their way home from a basketball game, the team is led to a wayward pastor and his brother. Also, Remy attends a hearing for his brother's murderer.

The team must navigate the mistrust of authorities in a tight-knit Somali community in Minnesota as they race to find a kidnapped 14-year-old girl.

When a rising star athlete is found violently murdered, the team chases after one of her teammates and his girlfriend; Remy reunites with a true crime show producer from his past.

The clock ticks as the FBI and FBI: Most Wanted teams join forces to hunt down the fugitive terrorists as they get closer to carrying out a plot to destroy a major New York City landmark and cause devastating civilian casualties.

The crossover starts on FBI: International S02E16 Imminent Threat (I) and FBI S05E17 Imminent Threat (II).

The team jumps into action to find two missing coeds after their roommate Carly Cassidy’s older brother is involved in a homicide that took place in their dorm room. Also, Hana becomes distracted when she meets someone online.

After two agents from the Bureau of Land Management go missing while executing a land seizure warrant in Wyoming, the Fugitive Task Force heads west to track them down in an unwelcoming county; Hana receives a threat.

When a news anchor is shot dead in the station's parking lot, the task force must dive into a story she was working on to track down her killer; Remy debates revisiting the case around his brother's murder.

The witness Remy and Kristen are visiting in prison is put in danger when a riot breaks out, leaving the staff and visitors held hostage by two murderous gangs.

The Fugitive Task Force searches for a missing migrant teen they believe was lured into unlawful work by a dangerous man. Also, Remy learns of a previously undisclosed witness in his brother’s murder case.

The team helps Remy try to catch his brother’s real killer 25 years after Mikey was murdered.