When Paul and Jamie drop their daughter Mabel off for her first day of college, it quickly becomes clear that they have very different ideas of what their lives after children will look like.

After too many surprise dorm visits, Mabel forces Jamie to sign a contract limiting contact for the next 48 hours, and suddenly Paul finds himself in the parenting hot seat.

Jamie makes the decision to get back into the work force, but time and menopause conspire against her. Meanwhile, Paul is invited to speak to Mabel’s class only after promising to Mabel that no one will know they’re related.

Jamie spins out when one of her meticulously crafted scrapbooks documenting Mabel’s childhood disappears. Meanwhile, Ira shocks everyone (himself included) when he asks Lucia to marry him.

Tonya oversees Jamie’s sessions as she transitions back into the workplace as a therapist. At the gym, Paul is going through a battle of his own as Mark is upset that Paul refuses to be naked around him.

Paul and Jamie pay a visit to the retirement home to visit Paul’s mother, Sylvia, and her new boyfriend, Ralph. Meanwhile, an unexpected visitor walks into Ira’s restaurant.

Paul and Jamie's concerns about mortality and getting their affairs in order are triggered when they attend the funeral of Paul and Ira's Childhood friend.

When Lisa is double-booked on her celebrity pet-sitting obligations, Jamie volunteers Paul to stay at Anderson Cooper's place, allowing him his first bachelor night in years.

Paul and Jamie are forced to make a tough decision about the future of their home when a wealthy buyer expresses interest in their apartment.

Paul and Jamie help Mabel deal with the fallout after a school experiment goes awry; Jaime stumbles upon an unconventional way Tonya can help Donovan overcome his sleepless nights.

Paul and Jamie try to plan a surprise birthday party for Mabel while she intends to reveal a big surprise of her own.